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Brain IDP

587 IDPs were divided into two categories including brain structure and brain structural connectivity and each was in up to 33,224 European adults. Brain structure includes 203 IDPs in cerebral cortex and 24 IDPs in subcortical regions. Brain structural connectivity includes 360 IDPs of white matter connections. All GWAS statistics of IDPs have been available on the Oxford BIG web browser (https://open.win.ox.ac.uk/ukbiobank/big40/). Details please refer to UK Biobank (UKB) online refs and we outlined briefly in here.
The reliability of these measurements is supported by previous studies[1-5].The tools or analyses to get these measurements are briefly described as follows:
   i.Cortical measurements were extracted by the FreeSurfer tool based on the Desikan-Killiany atlas[1].
   ii.Subcortical measurements were extracted by the FIRST tool[2] and the FreeSurfer tool based on the automatic subcortical segmentation[3].
   iii.The features of white matter connections were estimated from the diffusion MRI based on two complementary analyses, tract-based spatial statistics[4] and probabilistic tractography[5].
[1] Iscan, Z. et al. Test-retest reliability of freesurfer measurements within and between sites: Effects of visual approval process. Hum Brain Mapp 36, 3472-3485, doi:10.1002/hbm.22856 (2015).
[2] Nugent, A. C. et al. Automated subcortical segmentation using FIRST: test-retest reliability, interscanner reliability, and comparison to manual segmentation. Hum Brain Mapp 34, 2313-2329, doi:10.1002/hbm.22068 (2013).
[3] Fischl, B. et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341-355, doi:10.1016/s0896-6273(02)00569-x (2002).
[4] Smith, S. M. et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31, 1487-1505, doi:10.1016/j.neuroimage.2006.02.024 (2006).
[5] Behrens, T. E., Berg, H. J., Jbabdi, S., Rushworth, M. F. & Woolrich, M. W. Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? Neuroimage 34, 144-155, doi:10.1016/j.neuroimage.2006.09.018 (2007).