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BrainMR: Brain IDPs & Psychiatric Disorders

A Database of Causal Relationships between Imaging-Derived Phenotypes and Psychiatric Disorders

Note:
Forward MR: IDP → Disorder
Reverse MR: Disorder → IDP

Abbreviation:
ADHD, attention deficit hyperactivity disorder; AN, anorexia nervosa; ANX, anxiety disorder; ASD, autism spectrum disorder; BD, bipolar disorder; MDD, major depressive disorder; OCD, obsessive compulsive disorder; PTSD, posttraumatic stress disorder; SCZ, schizophrenia; TS, Tourette syndrome;
FA, fractional anisotropy; MD, mean diffusivity; MO, diffusion tensor mode; ICVF, intracellular volume fraction; ISOVF, isotropic or free water volume fraction; OD, orientation dispersion index.

Examples: hipp, hippocampus, or IDP.0018 (ID list of IDP refer to the browse or help page),or click here.

Welcome

Brain imaging-derived phenotypes (IDPs) can be measured noninvasively by magnetic resonance imaging (MRI), including the measures of the cortical surface area, thickness and volume in the distinct brain regions, and the structural connectivity of the white matter fibers. Mendelian randomization (MR) is an epidemiological method that uses genetic variants as an instrument to infer the causality between exposure factors and outcomes. We performed a two-sample MR framework to estimate causal risk factors of psychiatric disorders at the brain IDP level. We systematically screened bidirectional causal effects between 587 IDPs in 33,224 UK Biobank participants and 10 psychiatric disorders with the number of subjects ranging from 9,725 to 161,405.

Citations

To cite the results from BrainMR database, please cite our paper: Guo et al. Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders. Nat Neurosci. 2022 Oct 10. doi: 10.1038/s41593-022-01174-7.

Update

October 28, 2022:
[1] Revised the IDP name corresponding to the IDP ID (IDP ID from Smith et al., Nature Neuroscience, 2021)
IDP Name IDP ID Tissue/Region

Volume of the left rostral middle frontal cortex IDP.0369 Frontal lobe

Volume of the right rostral middle frontal cortex IDP.0402 Frontal lobe

Cortical surface area of the left rostral middle frontal cortex IDP.0674 Frontal lobe

Cortical surface area of the right rostral middle frontal cortex IDP.0708 Frontal lobe

Thickness of the left rostral middle frontal cortex IDP.1046 Frontal lobe

Thickness of the right rostral middle frontal cortex IDP.1080 Frontal lobe

FA in the splenium of corpus callosum IDP.1456 Commissural fibers

MO in the splenium of corpus callosum IDP.1531 Commissural fibers

MD in the splenium of corpus callosum IDP.1606 Commissural fibers

ICVF in the splenium of corpus callosum IDP.1906 Commissural fibers

OD in the splenium of corpus callosum IDP.1981 Commissural fibers

ISOVF in the splenium of corpus callosum IDP.2056 Commissural fibers
[2] Revised the counts of Frontal lobe (54) and Limbic system (30) categories in IDP regional classification.

Copyright © 2021 Biomedical Informatics & Genomics Center, Xi’an Jiaotong University, China. All rights reserved.